Coloplast Alterna NEW Мешок уростомный, прозрачный, фланец 60мм

Количество: 1 упаковка

Уростомный мешок Coloplast Alterna выполнен из многослойного прочного не шуршащего прозрачного полиэтилена, с дренажным сливным клапаном. Мешок покрыт с одной стороны мягким нетканым полотном, которое обеспечивает приятное и комфортное ношение, предотвращает шуршание мешка. Покрытие быстро высыхает, при необходимости можно вытирать полотенцем.

Многокамерное строение мешка позволяют сохранить плоскую форму уроприемника и не дают содержимому плескаться.

Большой удобный сливной клапан для дренирования калоприемника может соединяться с дренажной системой. Клапан выполнен из мягкого пластика. Он гигиеничен, капли мочи не попадают на внешнюю сторону клапана. Идеально подходит людям с ограниченной ловкостью рук. Кроме того, после опорожнения в мешке не остается мочи.

Антирефлюксный клапан предотвращает обратный заброс мочи в стому. Это препятствует возникновению инфекции мочевыводящих путей.

Фланцевое соединение с кольцом-защелкой двухкомпонентной системы удобно и надежно в использовании, при креплении мешка не оказывается давления на перистомальную область. Кроме того, мешок можно повернуть в любое удобное положение, не снимая с фланца пластины.

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Количество в упаковке: 20 шт

ПРОДАЮТСЯ ТОЛЬКО УПАКОВКОЙ! стоимость указана за упаковку.

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Гость08.03.2025

Our Favorite Serums And Oils For Gua Sha # Our Favorite Serums And Oils For Gua Sha ## Gua Sha 101 Gua Sha, also known as Guasha or Gua Zha, is an ancient Chinese beauty ritual tool used for facial massage. It involves using smooth, rounded stones to gently press and roll over the face, promoting blood circulation and lymphatic drainage, leading to a more radiant complexion. The practice is rooted in Traditional Chinese Medicine (TCM) and has gained popularity worldwide for its detoxifying and rejuvenating benefits. ## Best Gua Sha Serums and Oils for Oily Skin For oily skin, the goal is to control excess sebum production, reduce shine, and maintain a balanced complexion. These serums and oils work synergistically with Gua Sha to keep your skin matte and refreshed. **Viva Naturals Organic Jojoba Oil** Jojoba oil mimics the skin's natural sebum, making it an excellent choice for those with oily or acne-prone skin. 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Apply a few drops after cleansing and use Gua Sha to gently massage the face, focusing on areas like the cheeks and jawline, to promote circulation and hydration. **Josie Maran 100% Pure Argan Oil** Argan oil is a classic choice for dry and damaged skin. Its rich fatty acids nourish and protect the skin barrier, leaving it soft and supple. Apply a couple of drops to clean skin, then use Gua Sha to massage your face, emphasizing on areas prone to dryness like the temples and forehead. **Herbivore Emerald CBD + Adaptogens Deep Moisture Glow Oil** This oil combines CBD with adaptogens like Ashwagandha and Licorice Root to promote relaxation and skin health. CBD is known for its calming effects, which can help reduce stress-induced breakouts. The deep moisture formulation helps replenish the skin's hydration levels, making it perfect for dry and sensitive skin. Use it as a final step in your skincare routine before Gua Sha to lock in moisture and soothe your skin. ## Best Gua Sha Serums and Oils for Combination Skin For combination skin, the challenge is to balance oil production without stripping away necessary moisture. These serums and oils are designed to regulate sebum and maintain a healthy skin barrier. **Biossance Squalane + Vitamin C Rose Oil** Squalane is a lightweight, odorless molecule that mimics the skin's natural moisturizing abilities. Its combination with Vitamin C Rose Oil provides brightening benefits and helps reduce excess oil production. Apply a few drops to clean skin, then use Gua Sha to massage your face, focusing on areas like the nose and chin to help balance oil distribution. **Skinowl Geranium Drops** These drops are infused with plant-based extracts known for their ability to regulate sebum production and reduce bacteria on the surface of the skin. The lightweight formulation makes them ideal for combination skin. Apply a few drops after cleansing and use Gua Sha to gently stimulate your face, helping to clear congestion and maintain a balanced complexion. **Indie Lee Squalane Facial Oil** Squalane is a hero ingredient for anyone with combination or oily skin. This facial oil is lightweight and non-greasy, making it perfect for daily use. It helps reduce shine while keeping the skin hydrated. Use it as a primer before Gua Sha to create a smooth canvas that glows from within. ## Best Gua Sha Serums and Oils for Aging Skin As we age, skin can become dry, lose elasticity, and show signs of fatigue. These serums and oils are formulated to combat the signs of aging by boosting collagen production, protecting against oxidative stress, and promoting a more youthful appearance. **ÓLEO PARA A FACE Kaya Anti-Aging Face Oil** Kaya's anti-aging oil is rich in antioxidants like Resveratrol, which help protect skin cells from oxidative damage. Its nourishing formulation helps improve elasticity and reduces the appearance of fine lines. Apply a few drops to clean skin, then use Gua Sha to gently massage your face, focusing on areas like the orbital bone and cheekbones to stimulate collagen production. **Pure Restorative Sea Culture Replenishing Serum** This serum uses sea culture extract, a nutrient-rich ingredient that helps restore the skin's natural moisture barrier and improve its elasticity. Its anti-aging properties make it ideal for dry and aging skin. Apply a few drops after cleansing and use Gua Sha to encourage blood circulation, helping to rejuvenate your face. **Herbivore Bakuchiol Retinol Alternative Smoothing Serum** Bakuchiol is a natural alternative to retinol that has anti-aging benefits without irritation. This serum also contains adaptogens like Reishi mushroom extract, which help reduce stress and promote skin health. Apply it as part of your evening routine, then use Gua Sha to massage your face, focusing on areas like the brow bone and jawline, to help smooth out fine lines and improve texture. ## Related Stories - **The Art of Gua Sha: Ancient Beauty Rituals for Modern Skins** - **How to Incorporate Gua Sha into Your Skincare Routine** - **Expert Tips: Using Gua Sha Like a Pro** Also visit my web site legal steroid uk (<a href="https://bolaopaulista.com/author/elizabethew/">Carroll</a>)

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Гость13.03.2025

You will merely try to extend the intensity for the compound movements by rising the load to invoke progressive overload. If you jump weights and discover that you simply can’t full the rep range, merely take a rest and end up. As seen above, the biceps are actually a bit complex with it being a two headed muscle that crosses three joints. Therefore, to find a way to fully prepare the biceps as a complete, you want to use variability in your coaching. Personally, once we prepare biceps, we like to make the most of variability with the smaller train quite regularly. And after strapping some electrodes to my arm, I found the best workout routines to take action. Carry Out this exercise with a sluggish and controlled motion for one of the best results. If you're feeling any pain past your typical "burn," cease proper there. Any sharp pain means you need to take it down a notch to stay safe. By sustaining correct form, you will get swole with none pressure and make the most of your exercise. Your excellent body weight routine will at all times be unique to your needs. When you decrease yourself, transfer your left hand an inch to the proper. If you’re a newbie trying to get stronger within the bench press, take a look at our beginner bench press program. To me, one of the best bicep exercises are the ones that prioritize constant tension and a full vary of movement. Exercises like barbell curls or 21s might have their place, however they don’t deserve the highlight they usually get. They engage the arms, shoulders, back, and core in a single movement, making them a full upper-body exercise with just a single bar. Bettering your vary of motion by utilizing the preacher bench, which helps to increase the period of time the biceps are working time beneath tension. While many would say this is a commonplace again train, rows goal the biceps with such intensity that we love incorporating this move into arms training workouts. Do a set of dumbbell lateral raises after which, with out resting, immediately do a set of face pulls. Rest for the prescribed time and then repeat the pairing for the required variety of supersets. Begin with 5-10 minutes of easy cardio, such as rowing, air bike, elliptical, or leap rope. Next, do some dynamic mobility and suppleness exercises for the muscles and joints you’re about to use. Execute these three biceps workout routines correctly in your next arm workout and reap the rewards. Whereas it does require some setup, the bench cable curl is properly well value the effort, effectively isolating the biceps and delivering consistent outcomes. For these severe about achieving most growth, this train is very recommended. In different words, you typically just need extra size to make the definition extra visible and distinguished. To illustrate, it’s no good doing additional sets if they’re all 7-8 reps away from failure. If you have already got a low body fats level however nonetheless lack the biceps definition that you’re after, then there’s an excellent likelihood that your biceps merely need extra general mass. And as a result of each are additionally unilateral, they’ll make your biceps look extra symmetrical and aesthetic in addition to massive and muscular. It lets you concentrate on the target muscles (glutes and hamstrings) while performing this exercise. Of course, when you do have access to gear, you've a larger benefit of building your biceps as a end result of it is easier to progressive overload with weight and you will have extra train variety. However, even with just your body weight, you might have plenty of biceps workout routines, as you are going to see beneath. However ensure to rest 2 minutes between pairings so that you don’t see any extreme weight or repetition drop-offs between sets. You can even click on the link to learn how to build your biceps without weights or pull-ups if you’re coaching with out gear. By working smaller muscular tissues first in your exercise, you burn them out and require the bigger muscles to work even tougher to recruit more muscle fibers. As mentioned, you cannot isolate a single bicep head, however you'll have the ability to emphasize the lengthy or brief head by way of certain workout routines, as listed above. This exercise is similar to the first, but I recommend utilizing a different grip. If you have been doing underhand chin-ups, maybe do some overhand pull-ups. If you might have steel elbows, do whatever you like, however I don’t wish to give you golfer’s elbow. Not only do they put your biceps at a mechanical disadvantage and thereby pressure your brachialis and brachioradialis to do more work, but they’re also highly conducive to using the right kind. Now we move onto our foundational decrease body movement sample for energy using the Barbell Squat. Be positive you're performing this compound movement with appropriate form to minimize the risk of harm. The ultimate exercise, as I just alluded to, contains more training quantity than the first and is recommended if you’ve already received a couple of months of lifting expertise underneath your belt. I program curl bar squats into beginners’ train regimes after they've mastered the air squats. The curved heart of the EZ bar also prevents the bar from digging into the traps, making the coaching expertise comfortable. The ergonomic hand place of the curl bar lowers the strain on the shoulders and traps throughout upright rows. You may also get rackable curl bars, but there isn’t a lot utility to them. Yet, there’s also no have to live in the health club to get those gains. Select a weight at which you almost attain muscle failure, but do not go to failure during your first month. Now, while we’re right here, it’s worth mentioning that the EMG is just one way of assessing each train. Grasp a towel across the chin-up bar and seize all sides of it with your arms. However, having your arms at your sides limits the pre-stretch of the biceps, which could cut back the overall pressure. For those looking for a balanced method to constructing dimension and strength, the EZ bar curl is a strong selection and could be thought of one of the best bicep exercises for most individuals. I place this in the A-tier due to its consolation and effectiveness. The biceps have two origins, which means they have two uppermost attachment websites. The quick head originates on the scapula or shoulder blade, whereas the long head originates simply above the shoulder joint. These two attachments merge to kind a single muscle belly, which inserts onto the radius, which is the bigger of your two forearm bones. This may be tough to evaluate daily, which is why there’s a 4-6 rep vary. Nevertheless, your goal will be to both take away help OR add load whilst you stay in that range. Further, you also see the observe about performing an eccentric after the final set. For this, you'll pull yourself all the way in which up and then come down as sluggish as attainable (should be no less than 5 seconds). Additionally, under you'll notice that you might be able to alternate what arm curl you select in the biceps program. This volume, in turn, helps your muscular tissues to develop back larger and stronger as a outcome of they’re getting used to dealing with weights at very close proximities to muscular failure. Bicep supersets are highly effective for constructing muscle for 2 primary reasons. You can even check out our 30 minute bicep exercise if you need to see one other routine that’s not too long or brief. Second, you can do the train unilaterally (one arm at a time) to successfully double the resistance while making certain that both of your arms get equal work. Drag curls create an intense peak contraction and emphasize the lengthy (outer) head of your biceps. Make sure you’re squeezing your muscular tissues on the peak of each rep, particularly on your 7-set exercises. The biceps brachii muscle (biceps) is a big, thick upper arm muscle. It is hooked up to the forearm bone called the radius and originates on the scapula in two heads (short and Lengthy Head). The pressure is biggest when your elbows are at a 90-degree angle, and after that, it drops off. As a end result, it will not be one of the best bicep exercise for exciting full-range muscle development. To develop your biceps, the rep ranges will depend on the weights you've available and your skills. As supported by a evaluation printed in the Journal of Energy and Conditioning Research, for hypertrophy (building muscle) aiming for 6-12 reps ought to be sufficient. If you are doing a dumbbell arm exercise at an advanced level, especially for an skilled lifter, doing 3-4 totally different bicep exercises should be sufficient for muscle growth. You will likely want to experiment with totally different curl variations and incorporate depth methods for a sophisticated workout. You’ll also discover that both workout routines use the same gear; this is by design. If you prepare in a busy fitness center, it may be hard to do supersets for biceps that require totally different training tools as a end result of somebody could properly be using the gear that you simply want. By performing a bicep superset exercise routine, you'll be able to blast your biceps with unmatched intensity whereas saving tons of time in the process. Keep In Mind to try to improve the load you're utilizing in every exercise to ensure your continued muscle development and power positive aspects. If you’re a girl, however, then you can take a look at our back and bicep exercise for girls for a full routine. This muscle will make your arms look greater when they’re hanging by your sides (i.e., a lot of the time) by filling out the top of your forearms. If there’s one muscle group that every lifter needs to develop to the maximum, it’s the biceps. The finest full physique exercise routine is three occasions per week since you'll have just 3 workouts per week with 4 days of rest between your workouts, which is good for a beginner routine. For the newbie lifter, this sort of training will help maximize muscle gain till your health stage is ready for more superior workouts. When you enhance in experience levels, you can select a special type of coaching break up (such as a 5-day workout routine like push pull legs) that will assist you proceed to progress in your health journey. Extending and adducting the upper arm provides a singular stimulus to the long head compared to different dumbbell exercises. With regular follow, barbell arm exercises can help you obtain higher development of the arms. Barbell exercises sometimes allow you to raise heavier weights than dumbbell exercises. The barbell reverse wrist curl over a bench is an train that targets the forearm muscular tissues, significantly the brachioradialis and wrist extensors. Though we’re teaching you tips on how to outline your biceps, it’s essential to train your brachialis and brachioradialis muscular tissues as properly if you actually want your arms to look good. This positioning supplies a higher stretch within the biceps, particularly in the long head, making it a main alternative for those trying to add height to their biceps. Whereas it might be challenging for beginners as a outcome of strict type required, the incline curl pays off with impressive positive aspects. The preacher curl stands out as one of the efficient workouts for bicep growth. By permitting for a larger stretch at the beginning of the movement, it ensures most muscle activation. Switching from barbells to dumbbells provides distinctive advantages, particularly for these vulnerable to joint discomfort. Dumbbell curls allow larger wrist flexibility, which can ease pressure on the elbows and wrists. You’ll be starting with barbell curls to concentrate on building total mass. Then, you’ll hit some hammer curls to construct your brachialis and brachioradialis, which, as we established earlier, are two commonly neglected muscle teams. Finally, you’ll do dumbbells curls to ensure that each of your arms obtain equal work and thus grow roughly in proportion with one another. The straight bar curl is a sort of fundamental bicep workouts that simply keeps on producing positive aspects no matter how sturdy you get. Hence, it makes a wonderful addition to a complicated bicep exercise in addition to a beginner one. Not Like its dumbbell counterpart, the barbell curl enables you to overload your biceps with the heaviest potential resistance, so it’s perfect for building mass. While chin-ups and pull-ups are primarily considered again workouts, they're also efficient for bicep engagement. However, as a outcome of involvement of multiple muscle teams, these workout routines might not isolate the biceps sufficient for optimum growth. Cable curls offer the distinctive advantage of sustaining fixed rigidity on the biceps throughout the movement, one thing that free weights can’t always present. For T’s, identical concept right here however pull your arms out utterly broad to make a T with your body. For Y’s, pull your arms out at a 45-degree angle until your shoulder has full opened, then decrease your arms again down. Dannah Bollig, a licensed private coach, former division one athlete and the creator of The DE Method loves this transfer that might be a fantastic bicep and tricep exercise for females. Despite chin-ups not being an isolation exercise, they’re still some of the effective (and certainly the most accessible) bicep-builders of all time. Chin-ups and curls make for an excellent—if challenging—superset biceps exercise. In this respect, performing a biceps circuit is another efficient way to work your biceps very intensely and in a brief house of time. The next superset for biceps is the DB biceps curl, adopted by the biceps hammer curl. Feel free to surf to my homepage :: how are steroids bad for you - https://anunciosclassificados.org/author/luella04t06/

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Гость15.03.2025

The serum from the remaining separation tube was separated, labeled, and saved in micro centrifuge tubes at -80°C for later analysis. Following completion of the examine, samples have been analyzed for energetic testosterone, free testosterone, and cortisol with an enzyme immunoassay (EIA) assays using Goat-Anti-rabbit IgG (GARG) coated microplates. Assays were performed using a Jitterbug microplate shaker (Boekel Scientific-Philadelphia, PA) and a Tricontinent Multiwash Benefit microplate washer (Grass Valley, CA). Nonetheless, the unchanged myostatin circulation concentration in the FOR group didn't have an result on the molecular markers associated to myostatin-regulated signaling in skeletal muscle and didn't attenuate disuse-induced muscle atrophy. We note that 2 weeks of regular activity following two weeks of immobilization was insufficient to recover the decline in muscle CSA and peak torque throughout disuse. Numerous nutritional supplements are marketed as ergogenic aids to resistance-trained athletes in an try to promote increases in strength, power, and/or muscle mass throughout training. Over the previous couple of years, methoxyisoflavone, ecdysterones, and sulfo-polysaccharide (a purported myostatin inhibitor) have been marketed as potential anabolic selling nutritional dietary supplements for resistance-trained athletes. Unfortunately, little well-controlled research has been carried out to look at the potential ergogenic properties of those vitamins. Clinical research investigating the use of pharmaceutical myostatin inhibitors for stimulating muscle development have yielded underwhelming outcomes [13]. A Number Of latest analysis analyses conclude that animal models of myostatin blockade simply have not translated to human models [14, 15]. Epicatechin (EC) is a prominent catechin present in cocoa beans — and to a lesser degree in tea leaves — together with epigallocatechin gallate (EGCG), epigallocatechin (EGC), and epicatechin gallate (ECG) [3]. Epicatechin and related catechins have characteristically excessive antioxidant activity, making them enticing therapeutic candidates for oxidative stress-induced well being situations (e.g. heart problems, muscle atrophy, and continual inflammation) [4]. As discussed above, through the activations of various signaling processes, and thus, the activations of atrophic genes, MSTN interacts with a lot of totally different proteins, which supplies clues for the design of peptide inhibitors of MSTN. MSCs divide symmetrically to extend their number, or asymmetrically to produce cohorts of committed satellite tv for pc cells and consequently progenitors after they have been activated. Myogenic progenitors multiply and eventually differentiate by fusing with other myogenic progenitors or injured fibers so as to restore fiber integrity and function (Dumont et al., 2015; Dueweke et al., 2017). SM is composed of muscle fiber with a unique construction, which primarily consists of actin and myosin filaments that permit muscles to contract and chill out. Every muscle fiber represents a muscle cell, which has a elementary cellular unit generally known as the sarcomere. Fascicules are formed by bundles of myofibers, and muscle tissue is formed by bundles of fascicles, with every layer being contained by the ECM and maintained by cytoskeletal networks (Lieber and Friden, 2000). Another talked-about methodology of inhibiting myostatin is thru the consumption of epicatechin, a member of the flavonoid household of chemicals that management pigmentation in crops [31]. In both people and animals, myostatin is a hormone that acts as a type of "brake" that tells muscular tissues to cease growing, which helps to stop them from getting too giant. Uneven muscle growth is a risk if you don’t stick to a regimented coaching and recovery schedule. Unchecked muscle development can exhaust tendons and ligaments, growing the chance of damage. SwissChems is a trusted name within the peptide world, and their Myostatin delivers a potent method designed to focus on myostatin inhibition directly. Nevertheless, Welle did point out some unwanted effects within the mice come the end of the examine. You see, most roids or anabolics build muscle by making the muscle cells you have larger . Funding for this study was offered by a NASA Cooperative Agreement NCC8-242 to BioServe Space Technologies and in kind contributions of myostatin inhibitor from Amgen Inc. Thank you to the Leinwand Laboratory in the Department of Molecular, Cellular and Developmental Biology at the College of Colorado at Boulder for help with strategies development and access to laboratory resources. Subsequently, sustaining muscle during weight reduction is important to maintaining a wholesome weight over time. Hence, when performing a therapeutic realignment of the spine and distal joints, tight muscular tissues and weak muscles dramatically influence the end result of therapeutic interventional help. In this chapter, we evaluation myostatin biology, together with intracellular and extracellular regulatory pathways, and the function of myostatin in modulating physiologic processes, such as muscle development and growing older. Moreover, we focus on probably the most related experimental and clinical proof supporting the extra-muscle effects of myostatin. Lastly, we think about the principle methods developed and tested to inhibit myostatin in clinical trials and focus on the limits and future views of the analysis on myostatin. However, elevated ranges of CRP result in a reduction of the muscle cell dimension and result in sarcopenia [132]. A multivariate biomarker strategy has been proposed because the optimal means for identifying wasting illnesses, along side scientific indications and manifestations. Skeletal muscle (SM) comprises ~40% of body weight and is essentially the most dynamic organ, with an incredible capability to regenerate and repair after harm or trauma [1,2]. SM is liable for the maintenance of postural assist, motion, thermogenesis, and blood glucose homeostasis [3,4]. It was demonstrated that acute (24 h) UA therapy improves each basal and insulin-stimulated glucose uptake in human skeletal muscle cells, and that these results may be mediated by the upregulation of GLUT4 expression. Collectively these findings recommend believable translation into human research of obesity and ageing, the place these effects, must be investigated additional. It have to be thought of that parent UA is not the dominant type throughout the circulation. Rather, its phase II metabolites (predominantly UA-glucuronide and UA-sulfate) abound in far higher concentrations [23]. There is a few proof that UA conjugates have proven decrease organic potency in vitro, in comparability with mother or father UA, on the bioactive anti-proliferation impact [13]. Cordycepin, also called 3′-deoxyadenosine, is a key lively element present in Cordyceps militaris17. This compound displays varied pharmacological effects, such as potent antioxidant10, anti-inflammatory11, and neuroprotective effects12. A earlier examine demonstrated that cordycepin reduces the restoration time from muscle fatigue in isolated skeletal muscles13. To examine the anti-fatigue mechanism of cordycepin, we initially examined the effect of H2O2-induced oxidative stress on C2C12 cells, after which evaluated the antioxidant properties of cordycepin by assessing the viability of C2C12 cells. After four days of induced differentiation at 37 °C in a 5% CO2 incubator, cells had been pretreated with varied concentrations of cordycepin (0.1, 0.5, and 1 μM) for 24 h. MSTN binds to the ACVRIIB and ALK4/5 advanced leading to successive phosphorylation of Smad2/3, resulting in its binding with Smad4 and translocation of the advanced to the nucleus. Non-Smad signaling, then again, tends to suppress the AKT intracellular signaling pathways. The program was standardized at three units of 10 repetitions with as much weight as they could lift per set (typically 60 – 80% of 1 RM) with no extra than 2-minute rest durations between sets and no extra than three minutes of relaxation between workout routines. Subjects recorded the amount of weight lifted and number of repetitions carried out for every set on training playing cards so that coaching volume might be decided. Topics had been also instructed to have their exercise card signed by SLC staff in order to verify attendance and completion of the exercises. After performing in silico screening, the consequences of MIF1 and MIF2 on C2C12 myoblasts were evaluated, and each peptides were discovered to reinforce myoblast proliferation and differentiation by inducing the expression of myogenic marker genes. C2C12 cells have been cultured in development medium till 70% confluent and the medium was then switched to myogenic differentiation medium supplemented with MSTN-protein, Ac-MIF1 or Ac-MIF2-NH2 for 3 days. Fusion indices were calculated for MSTN-protein-treated, Ac-MIF1-treated, Ac-MIF2-NH2-treated, MSTN-protein + Ac-MIF1-treated, and MSTN-protein + Ac-MIF2-NH2-treated cells. These data indicate that Ac-MIF1 and Ac-MIF2-NH2 peptides inhibit the effect of MSTN. A Quantity Of strategies have been used to develop remedies for SM-related problems, and computational approaches present a powerful technique of designing and creating new therapeutics. It wasn't until hardcore bodybuilders began experimenting with myostatin inhibitors that everybody began to understand simply how powerful they might be for muscle development. At sacrifice, lean body mass (LBM) was recorded as the carcass mass after elimination of head, pores and skin, and subcutaneous adipose tissue. Hindlimb muscles together with the left facet quadriceps, tibialis anterior (TA), extensor digitorum longus (EDL), soleus, plantaris were collected, weighed and snap frozen in liquid nitrogen for subsequent analysis. The calf complex (soleus/gastrocnemius/plantaris) from the proper limb was collected, frozen on cork in liquid nitrogen cooled isopentane and stored at −80 °C for subsequent histological evaluation. Earlier, we investigated several ECM proteins, particularly, FMOD (Lee et al., 2016; Lee et al., 2018), matrix gla protein (Ahmad et al., 2017), and dermatopontin (Kim et al., 2019), that play important roles within the regulation of myogenesis. MSTN is thought to inhibit the transcription elements Pax7, MYOD, and MYOG and thereby, regulate MSC proliferation and differentiation (Joulia-Ekaza and Cabello, 2006; McFarlane et al., 2008). Curiously, it was observed FMOD bypassed the inhibitory results of MSTN and maintained its transcriptional activity. We showed that FMOD instantly sure with MSTN in myoblast differentiation by co-immunoprecipitation. This seaweed extract can also be famous for its anti-inflammatory properties, which can help scale back muscle soreness and pace up restoration, permitting for more intense and frequent training sessions. Under, we focus on a few of the hottest and efficient elements utilized in dietary supplements that are identified to impression myostatin levels or activity. So the researchers ponder whether creatine, leucine and HMB can reinforce every other’s myostatin inhibitory impact. This thought turns into extra believable when you keep in mind the proof that leucine and HMB probably stimulate muscle progress via completely different mechanisms. ResultsAs a result of the myostatin, the muscle cells produced much less MyoD, however the presence of leucine, HMB and creatine corrected this. The supplements had been offered pre-mixed into a chocolate pudding to match the flavour and texture to maintain blinding. Epicatechin is a natural plant compound from a powerful group of phytochemicals often known as flavanols. Consuming foods rich in epicatechin as well as adding a prime quality epicatechin complement may allow you to increase circulation, improve your heart health, promote muscle progress, and even protect you against age-related muscle losing and different well being issues. As a natural anabolic compound, laxogenin stacks well with epicatechin to boost muscle development. Two serum separation vacutainer tubes and one EDTA vacutainer tube was obtained from each topic. The serum vacutainers have been separated by way of centrifugation a 6,000 rpm for 20 minutes. One serum separation tube and the EDTA tube were sent to Quest Diagnostics (Dallas, TX) for assay of a regular scientific chemistry profile and complete blood cell counts to ensure security of supplementation through the protocol. Myostatin negatively regulates protein synthesis by way of the Akt pathway by inhibiting Akt/p70s6k activation30 and signaling31. Myostatin increases protein degradation by way of activation of the ubiquitin–proteasome system10 and is mediated by way of elevated expression of the ubiquitin e3 ligases Atrogin-1 and MuRF-131,32,33. Therapies focusing on the myostatin pathway thus hold promise to mitigate muscle atrophy that accompanies disease and disuse34,35. Preliminary outcomes from a research only available in abstract form [18] evaluated the consequences of 5-methyl-7-methoxyisoflavone supplementation (800 mg/day for 8-weeks) on coaching diversifications in 14 resistance-trained males. Inclendon et al[18] reported 5-methyl-7-methoxyisoflavone supplementation did not considerably have an result on adjustments in physique weight, body mass index, bone mineral content, or isokinetic peak drive between teams. Nonetheless, DEXA decided FFM elevated by 1.three kg in the methoxyisoflavone group whereas being unchanged (0.1 kg) in the placebo group resulting in a major reduction in body fat %. Results of the current examine do not help the purported ergogenic value of 5-methyl-7-methoxyisoflavone supplementation in resistance-trained males. Though MSTN just isn't extremely expressed in adipose tissue, it performs a major position in mediating adipose tissue function. Metabolically, MSTN-null mice present elevated power expenditure and leptin sensitivity [137]. Inhibition of MSTN upregulates enzymes involved in lipolysis and mitochondrial fatty acid oxidation, increasing fats breakdown in peripheral tissues, and decreasing lipid accumulation [138]. The effect on skeletal muscle progress  is certainly one of the primary reasons for the huge interest for epicatechin lately. One examine was capable of decide that epicatechin from dark goodies inhibits myostatin. Low ranges of myostatin protein are fascinating as a outcome of it leads to increased capacity to build skeletal muscle mass. Phenolic compound resveratrol has anti-inflammatory and antioxidant properties that encourage the manufacturing of more antioxidant-related enzymes and activate transcription components like NRF2 [189]. As a outcome, it might hinder the degradation of proteins, which is primarily brought on by the angiotensin I and II routes, and phorbol ester via minimizing the expression of MAFbx, MuRF1, and NF-κB [190]. Furthermore, elevated NRF2 gene expression has been linked to the regulating of pro-inflammatory cytokines, primarily IL-6 and TNF. Myotube formation was increased by Ac-MIF1 (11%) or Ac-MIF2-NH2 (14%) (Figure 4B). MYOD, MYOG, MYL2, and MYH mRNA ranges and MYOD, MYOG, and MYH protein levels had been elevated in Ac-MIF1-treated cells, and MYOD, MYOG, MYL2, and MYH mRNA and proteins levels were elevated in Ac-MIF2-NH2-treated cells. Mouse major MSCs had been cultured with differentiation media supplemented with Ac-MIF1 or Ac-MIF2-NH2 for three days. MYOD, MYOG, MYL2, and MYH mRNA expression and MYOD, MYL2, and MYH protein expression have been elevated in Ac-MIF1-treated cells, and MYOD, MYOG, and MYH mRNA and MYOD and MYH protein expression have been increased in Ac-MIF2-NH2-treated cells (Supplementary Figure S5B). Curiously, MSTN protein ranges had been decreased in Ac-MIF1- and Ac-MIF2-NH2-treated cells (Figure 4C,D). In addition, Atrogin1 and MuRF1 mRNA ranges and ACVRIIB protein ranges had been decrease in Ac-MIF1-and Ac-MIF2-NH2-treated cells than in non-treated controls (Supplementary Figure S6). In addition, Smad3 expression was significantly decreased in Ac-MIF1- and Ac-MIF2-NH2-treated C2C12 cells. People claiming the capacity to carry larger weights have reported improved performance in workout routines corresponding to bench presses. Some customers have even claimed deadlift enhancements of as a lot as 50 kilos whereas using YK11. Promising to spice up absorption of epicatechin by as a lot as 200 to 600%, Ep1logue by Olympus Labs promises to help improve circulation to your muscle tissue during your workouts for optimal vascularity, vitality, and performance. Reviewers have seen constructive effects with a variety of coaching stimuli and rep ranges. There have been nearly no epicatechin unwanted aspect effects reported in the literature, so it is thought-about a safe complement for any healthy adult, including girls. Women, simply ensure you choose an epicatechin complement that is free of any testosterone boosters. We wish to thank the themes that participated on this research and the laboratory assistants in the Train & Sport Vitamin Lab (ESNL) who assisted with data assortment and evaluation. SRK-015, just lately designed by Scholar Rock for the remedy of SMA, is a monoclonal antibody that inhibits the activation of myostatin. In vivo, SRK-015 analogs effectively improved muscle mass and function in mouse fashions of SMA [69] and prevented muscle atrophy induced by dexamethasone remedy [68]. SRK-015 is currently being investigated in a part 2 scientific trial in sufferers with SMA. Theoretically, lower myostatin ranges will allow muscle cells to differentiate and proliferate at a greater fee. Research has certainly found an inverse correlation between circulating myostatin ranges and lean muscle mass [16]; in other words, individuals with decrease myostatin levels are likely to have extra muscle mass and vice versa. Curiously, myostatin expression increases rapidly after skeletal muscle disuse (e.g. being on bed relaxation for several consecutive days) [17]. It is conceivable the combination of flavonols and phytochemicals present in pure cocoa might have a unique impact on skeletal muscle adaptation to train. Another facet of (–)-epicatechin supplementation worthy of additional research is the timing and length of supplementation. As An Alternative of continual supplementation, it might show beneficial to look at the utilization of (–)-epicatechin when supplemented immediately previous to exercise. Research have shown (–)-epicatechin will increase blood flow through vasodilation by the use of nitric oxide manufacturing (3). Lastly, the potential inhibition of aerobic diversifications in skeletal muscle as a result of the antioxidant properties of (–)-epicatechin must be immediately examined. Also visit my web blog: <a href="https://xossipy.com/user-224367.html">steroids that start with p</a>

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Гость27.03.2025

No a couple of serving per day is recommended, and to keep away from sleeplessness, the product should not be taken inside six hours of bedtime. Right Now, that data could be discovered online, and several other trade specialists have stepped as a lot as meet that demand. One such professional is Dr. Jim Stoppani, a Ph.D. in exercise physiology, former senior science editor for a quantity of main health magazines, and founder of JYM Complement Science. He has become certainly one of today’s most well-known and trusted consultants within the health, nutrition, and train science business. It’s good to see a critical dose of six grams of citrulline on this Pre Jym exercise review—which can cut back recovery time between sets, give a powerful pump, and improve endurance. The Pre-JYM X stands out with its unique mixture of components, together with betaine nitrate, citrulline nitrate, pine bark extract, and increased dosages of creatine HCl and beta-alanine. It additionally features novel stimulants like methylliberine and theacrine, paired with theanine for a clean but intense power and focus enhance. The supplement is clear about its components without any proprietary blends. This increased blood move is assumed to enhance oxygen and nutrient supply to your muscle tissue, doubtlessly bettering endurance and decreasing fatigue. L-tyrosine may enhance cognitive performance and scale back blood strain in stressful conditions.[9] But to see any real effects, you’d need a dose of 100–150 mg per kg of physique weight. He has been lifting weights & writing about fitness for over 5 years. He has been a contributor for a quantity of health and fitness publications, including WealthyGorilla.com, MuscleAndBrawn.com. The mixability is definitely better than the POST, which we've established as notoriously poor. It’s less of a priority with this product though it is occasionally powdery at the backside of a 500ml drink. I didn't expertise a lot with this product, even compared with competitors in the marketplace. Had a lot power after the first use when I obtained home I cleaned out my garage. I won't bore you guys with a evaluation that claims the identical thing as all different evaluations, just worded in another way. This is an affordable choice but it’s essential to keep in mind that this is going to be a key participant in bodybuilding-style coaching. If you’re not chasing the pump and also you wish to improve efficiency in different areas – strength, power, endurance – this isn’t for you. If you’re looking for one thing to drive extra efficiency, power, and overall output from your exercise, then Pre Jym X is price choosing up, even more so if you ever used and enjoyed the original Pre Jym. So these two ingredients confer a small advantage to Pre-JYM. For Beta Alanine issues are pretty clear, the recommended dose is 2-5 grams. So 2 is on the lower finish, but enough however 3.2 is extra of a normal dose. There are some issues with the tingling effect(paresthesia) of Beta-Alanine which can be eliminated by smaller dosages. The caffeine and different elements have been preserving me alert and targeted like none different. Cardio acceleration appears easier and I by no means knew what people meant once they said something gave them a "pump" but when I did biceps yesterday, I lastly got it. My biceps had been tight and powerful when I was doing curls, and I can only attribute this to Pre JYM. I feel awesome and I'm certain this product will continue to be in my common rotation. Oh, and while the product does not taste EXCELLENT, it does taste VERY GOOD for a preworkout supplement. But there is much more to this supplement than those key features. The excessive quantities of each ingredient also offer you a better method for figuring out. While you may get 3-4g of citrulline to improve your blood flow for a exercise, Pre JYM supplies the optimum amount of 6g of this amino acid. The ingredients in the Pre Jym Pre Exercise are supposed to enhance your pumps within the health club, which will increase blood flow to the muscle tissue. It Is got a number of components corresponding to Beta Alanine, L-Leucine, and Taurine, all of which have been clinically proven to enhance pumps. None of them are too beneath dosed, like is usually widespread in generic pre exercises. 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Гость30.03.2025

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Гость20.03.2025

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Гость26.03.2025

I’m able to get back into strength training after having two youngsters over the past three years. Between work, kids, cooking, and every little thing else that goes into being an grownup, discovering time to train just hasn’t been excessive on my precedence listing. Creatine monohydrate has been widely studied and is taken into account the simplest type of creatine. However one other type, creatine hydrochloride, reveals promise as being both effective and possibly easier to digest because of its absorbability. "Micronized" means the creatine particles have been mechanically processed to make them smaller, enhancing their solubility and absorption when consumed. "There was a slight grittiness, which I probably wouldn’t have seen if I wasn’t directly comparing it with Nutricost or Klean Athlete’s creatine powders. During testing, McGrane noted that the product has zero taste or aftertaste, making it simple to drink on its own or combine into smoothies, shakes, or different pre-workout meals and beverages. Our product recommendations are purely editorial, and while we may obtain free products to check and review, we only recommend the merchandise we're most impressed by. We never let retailers or public relations contacts dictate our content material or product coverage, which is why you possibly can belief us to offer you dependable and unbiased product suggestions. eleven milligrams of zinc per day to help immune perform, wound healing, and reproductive well being. Here are our top picks primarily based on elements, effectiveness, flavor, and value. Creatine monohydrate gummies are a comparatively new type of creatine complement that has turn into increasingly popular among men. One of the necessary thing benefits of creatine gummies is their ease and convenience of consumption. In Distinction To different types of creatine, similar to powder or liquids, gummies don't require any mixing or measuring, making them a perfect possibility for males who are all the time on the go or have busy existence. Model status is another essential issue to suppose about when choosing a creatine monohydrate supplement for men. The complement business is huge and numerous, with many producers advertising their products as one of the best in the marketplace. Subsequently, it's crucial to research the model and collect data on its status earlier than buying a product. Its research-backed benefits, quality, and purity are its main advantages. However, the upper price and limited research compared to creatine monohydrate might affect users' preferences, relying on their particular goals and price range. There is restricted research on the protection of creatine supplementation in pregnant girls. 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Drugs don’t have to dissolve in water and creatine breaks down in the abdomen, so there’s not a lot benefit. Whereas creatine would not instantly trigger weight loss, its influence on workout efficiency not directly contributes to shedding undesirable kilos. Enhanced workout performance results in elevated calorie expenditure and improved fat loss during exercise. It Is about tapping into the advantages that creatine supplementation presents, irrespective of gender, and embracing its potential to raise your health expertise. Balancing the worth with the potential dividends in your health progress showcases your strategic strategy to creating a reasonable investment. This transparency guarantees purity, allowing you to make a well-informed selection about what you welcome into your physique. Delving into the composition of the supplement empowers you to proceed with confidence, making certain that your selection resonates together with your fitness journey, working in the direction of your targets with precision. Naked Creatine Powder is a top-ranking complement filled with creatine monohydrate to learn the human physique with physical positive aspects, energy, and endurance. Vegan Creatine supplements include pure creatine that is lab-made with 2 chemical substances in a reactor, without the use of any animal merchandise, byproducts including gelatin-based capsules. No Matter you’re in search of within the creatine division, we’ll show you beneath how to sift apart high-quality creatine supplements from the so-so options. EcoWise's gummies are micronized for better absorption and are available mango and strawberry flavors, while Bageto's are available in a blended berry taste. Additionally, EcoWise contains turmeric and black pepper extract to reinforce absorption. 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Гость27.03.2025

Have been a very long time fan of Jim Stoppani and his workouts. I was actually joyful to see this product come alongside particularly because it includes the particular elements he recommends for pre-workout but conveniently put collectively, at a good price point. I discovered my power and energy ranges stayed fairly steady all through and I wasn't as fatigued as regular throughout my ultimate units. It taste extra like a delicate drink versus a workout supplement. After years of working out and trying completely different pre exercises, i can lastly say THIS is the present stopper of em all. This might be kind of significant depending on whether or not you would possibly be on a budget or not. Alpha-Glyceryl Phosphoryl Choline – Usually known as GPC, Alpha-Glyceryl Phosphoryl Choline is an efficient development hormone promoter as nicely as a robust, pure focus complement (2). We had been very excited to see GPC in Pre-JYM by incontrovertible reality that many professional bodybuilders complement with GPC on the aspect. Betaine – Betaine is a little bit of a mystery as to ‘how’ it really works, although the final consensus is that Betaine will increase pump and triggers enhanced muscle development. However, to get the full benefits, you will want to supplement with an extra 1.2 to 3 grams of beta-alanine daily to hit medical dosages (timing doesn’t matter). Currently, there’s no money back assure that I could discover for this Pre Jym exercise evaluate. This listing includes alcohol, amino acids, fluoride, wool, plastic, and contraceptives. I bought a wheelbarrow the other week—it had a most cancers warning. However for me—I don’t believe it has a place in a pre-workout. Authorized muscle-building complement that's designed to imitate the consequences of dianabol without all unwanted side effects. We’re not saying it’s bad – it definitely compares nicely to different products that use cherry-limeade (such as the C4 Ripped) – however it’s not noteworthy. It’s a nice taste expertise however that’s about as much as we will say of it. Equally, this product kicks ass in relation to the choice of mental assist compounds. The Pre Jym Pre Exercise, designed by Dr. Jim Stoppani, has 300mg of caffeine per serving. This, combined with the Bio-Perine to reinforce bio-availability, makes it an excellent pre exercise with an excellent quantity of caffeine suitable for intermediate or superior lifters. Most pre workouts don’t have any amino acids in them, which is why, in my opinion, Pre Jym stands out. Pre JYM contains each of our primary strength ingredients at nearly precisely the dosages we cite above. Elements are dosed on the amount proven effective in medical trials. Nonetheless, we have yet to discover a fat-burning complement in powder form that tastes good. The profit this could present is for some extra motivation to stick along with your food plan and exercise routine. If you’re doing extended fasting intervals, it might additionally help you battle these urges to achieve for snacks. NO3-T® nitrates work to promote better blood flow, delivering oxygen, hormones, and nutrients to your muscular tissues. However we believe that our process helps you perceive our expertise with every product, together with giving you sufficient info to accurately evaluate products to one another. Next I suppose we should discuss about the Caffeine comparison(as well as a word on L-Theanine). So in my thoughts, 300 MG of Caffeine and 350 MG of Caffeine are big doses and are roughly equal. It has a great dose of acetyl-l-carnitine, which has been linked to improved train performance and muscle recovery [7]. While neither could be considered one of the best pre-workout supplement—Pre Jym is more powerful, with larger doses of caffeine, beta-alanine, and creatine. Plus, many of C4 elements are hidden away in a proprietary mix. Protein spiking refers to companies that fill their ingredient mix with individual amino acids corresponding to taurine, glutamine or creatine to boost the overall protein content. For example, even though a label may say it accommodates 20 grams of protein, the individual amino acids depend as part of this whole. I really like JYM products but this method is basically lackluster. It is simply missing far too many core T boosting elements to be efficient. References: https://gitea.chaos-it.pl/kristopher24y7 https://git.pm-gbr.de/sanfordrowntre https://git.newai.day/philomena8649 https://gitea.adminakademia.pl/earnestine9563 https://geogebra.acatlan.unam.mx/ariannemeyer09 https://51.38.125.112/lucas44c24399 http://git.scraperwall.com/mammied334943 https://139.198.116.121:5020/mnvteena779936 https://git.wun.im/nereidaepperso https://repo.getmonero.org/rodrickmcilvai http://git.dashitech.com/damonseaman919 https://imidco.org/quincy82q48976 http://xintechs.com:3000/sharonhoinvill http://share.pkbigdata.com/stormyswartwoo https://src.eruta.nl/joereiniger520 https://gitea.tmartens.dev/penneyfegan267

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Гость27.03.2025

"The stronger your deadlift, the higher equipped you’ll be to do things throughout your day with out hitting muscular fatigue," she mentioned. Research confirmed that when looking on the load of the barbell, a lifter's single leg squat efficiency was 42% of the again squat¹. While it's pretty apparent you're going to lift less weight throughout a one leg deadlift, lifters nonetheless tend to lean towards higher reps (8-12). This puts it into the hypertrophy, or muscle progress, coaching zone. By pausing mid-lift, you extend the duration your muscle tissue are actively working. This elevated TUT locations greater demand on the posterior chain, notably the hamstrings, glutes, and lower back, promoting muscle progress and endurance. With the entice bar’s hexagonal shape and impartial grip handles in the heart, you’re able to grab the load at a extra pure angle—and still be capable of lift heavy like with a straight bar. For most deadlift benefits, you need your decrease back, obliques, and stomach muscle tissue working as a group to keep your spine stabilized. They’re good for a lot of things like; fitness center positive aspects, sports, safety, variation. Just going for the same sort of deadlift week in and week out can get boring. But, in case you are utilizing the platform-free method described above, you solely want one band. Be warned, this could make locking your deadlift out very difficult. Merely load your bar and roll it, so it is near the pegs, and then loop a band over each end of your bar and over the pegs. It actually feels as if the bar is being ripped out of your hands. Deadlifts are an superior exercise, however even this exercise can become boring if that’s all you ever do. The deadlift is likely considered one of the three big lifts for a reason; it's going to get you stronger. You should use the progressive overload principle to make consistent gains. Increasing the training quantity and depth or reducing the remainder period between units are efficient methods of overloading your muscular tissues. My name is Ashley Rhodes and I am a passionate fitness fanatic and blogger based in Los Angeles, California. After fighting my own health and weight challenges in my 20s, I found the transformative power of train, vitamin, and mindset work. Are you struggling with your deadlifting approach and need to fine-tune your form? Have you tried totally different variations but cannot fairly figure out which muscle tissue you're working or how to engage them properly? The hex bar deadlift, if accomplished with correct type, can dramatically change your physique. If you raise the weight slowly, there's a real probability you will not full your carry. Get access to the latest health and health insights, tools and particular presents to keep your profession moving. If you are in search of a substitute for the Romanian deadlift, take a look at my article on the Greatest Romanian Deadlift Options. This exercise is great for both men and women, and lots of representatives of the honest sex think about it considered one of their favorites. We are fun loving household that lives on a small farm and tries to be wholesome. We are not fitness fanatics we're just making an attempt to keep issues easy particularly with how busy our lives are. The single-leg deadlift is a good train for anyone who needs to work on their total energy, steadiness, and stability. The wider stance has a shorter vary of movement nevertheless it also allows you to raise bands with the next tension stage than the standard deadlift. I would certainly advocate the hex bar deadlift to anyone who's learning the deadlift mechanics. A more advanced variation of this exercise is the deadlift with dumbbells on one leg. Also, having properly devolved stabilizing muscular tissues for this exercise is a must to keep away from any pointless injuries. The dumbbell deadlift, together with the squat, is probably the most basic exercise in the whole arsenal. It is this a part of the muscle groups of our body that this exercise masses. References: https://conspiracytheoristdating.com/@keithfifield68 https://rhapsodyofrealities.abilliontestimoniesandmore.org/@hayden3863680?page=about https://datekid.com/@bfgdorie42232 http://iskame.bg.cm/@anthonyborovan https://islamichistory.tv/@devon96f667092?page=about https://subamtv.com/@anthonyy10002?page=about https://datekid.com/@bfgdorie42232 https://soundcashmusic.com/joellenullatho https://kannadatube.in/@tfaderrick8618?page=about https://www.tinguj.com/teganelisha73 https://iu.vua.me/@lakeisha76727 https://croart.net/bernien134461 https://rapostz.com/@markowashingto https://playidy.com/@lakeishacolema?page=about https://music.white-pilled.tv/titroberta8196 https://bantoomusic.com/franoglesby750

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Гость27.03.2025

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17639 (1759) Coloplast Alterna NEW Мешок уростомный, прозрачный, фланец 60мм

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